Safety limits of cathodal transcranial direct current stimulation in rats

  title={Safety limits of cathodal transcranial direct current stimulation in rats},
  author={David Liebetanz and Reinhard Koch and Susanne Mayenfels and Fatima Barbara K{\"o}nig and Walter Paulus and Michael A. Nitsche},
  journal={Clinical Neurophysiology},

Safety parameter considerations of anodal transcranial Direct Current Stimulation in rats

A safety study of 500 μA cathodal transcranial direct current stimulation in rat

The results showed that the current density inside the brain was less than 20 A/m2 during tDCS treatment in computational model, which indicates that 500 μA cathodal tDCS was safe for rodents.

Safety of Special Waveform of Transcranial Electrical Stimulation (TES): In Vivo Assessment

The short- and long-term stimulations did not induce significant adverse effects on brain and scalp tissues upon assessing biomarkers and conducting histological analysis, and there was no obvious edema or cell necrosis seen in cortical histology after the intervention.

Cathodal transcranial direct current stimulation induces regional, long-lasting reductions of cortical blood flow in rats

Cathodal tDCS induces a regional, long-lasting, reversible decrease in CBF that is not limited to the region to which tDCS is applied.

Electric Fields Induced By Transcutaneous And Intracranial Current Injections In The Rat Brain

  • A. AsanSinan GokM. Sahin
  • Biology
    2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
  • 2018
A rat model was used for in vivo investigation of the vertical electrical (E) field distribution due to electrodes placed over the skin and through a craniotomy hole and the results showed that the E-field was maximum immediately under the anodic electrode and decreased both in the vertical and horizontal directions rapidly by distance.

Preliminary Study on Safety Assessment of 10 Hz Transcranial Alternating Current Stimulation in Rat Brain

The results of magnetic resonance imaging and histopathological imaging indicated that the conditions applied provided safe tACS without damaging brain tissues or neuronal components in the acute phase, and the temperature did not increase above 41 °C, which is a temperature limitation for contact-type medical devices, even after 20 min of tACs application.

Safety of anodal transcranial direct current stimulation with respect to blood-brain barrier permeability in the rat

The present results indicate that anodal tDCS is relatively safe compared to cathodale tDCS, and does not affect BBB permeability or Claudin-5 expression levels under relatively high current stimulus conditions.

Transcranial Direct Current Stimulation: Protocols and Physiological Mechanisms of Action

It will be discussed how specific stimulation parameters, like stimulation intensity, duration, electrode size, and configuration, including recently developed new stimulation protocols, determine the direction, magnitude, and duration of effects.

Transcranial direct-current stimulation increases extracellular dopamine levels in the rat striatum

Findings suggest that tDCS has a direct and/or indirect effect on the dopaminergic system in the rat basal ganglia.



After-effects of transcranial direct current stimulation (tDCS) on cortical spreading depression

Pharmacological approach to the mechanisms of transcranial DC-stimulation-induced after-effects of human motor cortex excitability.

It is suggested that polarity-driven alterations of resting membrane potentials represent the crucial mechanisms of the DC-induced after-effects, leading to both an alteration of spontaneous discharge rates and to a change in NMDA-receptor activation.

Treatment of major depression with transcranial direct current stimulation.

The effects of 5 days of anodal stimulation of the left dorsolateral prefrontal cortex in 10 patients with major depression are investigated, finding a significant decrease in the Hamilton Depression Rating Scale and Beck Depression Inventory scores when compared with baseline that was not observed in patients that received sham stimulation.

MRI study of human brain exposed to weak direct current stimulation of the frontal cortex

Noninvasive cortical stimulation with transcranial direct current stimulation in Parkinson's disease

There was a trend toward a significant correlation between motor function improvement after M1 anodal–tDCS and MEP area increase, and the notion that cortical brain stimulation might improve motor function in patients with PD is extended.

Transcranial direct current stimulation and the visual cortex

Influence of transcortical d-c currents on cortical neuronal activity.

GABAergic modulation of DC stimulation‐induced motor cortex excitability shifts in humans

It is shown that pharmacological strengthening of GABAergic inhibition modulates selectively the after‐effects elicited by anodal tDCS, which results in late‐occurring excitability enhancement in the human motor cortex.