Safety issues related to retroviral-mediated gene transfer in humans.

@article{Cornetta1991SafetyIR,
  title={Safety issues related to retroviral-mediated gene transfer in humans.},
  author={Kenneth G Cornetta and Richard A. Morgan and William F. Anderson},
  journal={Human gene therapy},
  year={1991},
  volume={2 1},
  pages={
          5-14
        }
}
The first three approved human clinical trials utilizing retroviral-mediated gene transfer are now underway. While this technology holds great promise for the study and treatment of human disease, it also poses a number of safety concerns. In evaluating clinical protocols, potential complications and the likelihood of their occurrence are estimated by review committees so that a risk/benefit assessment can be made. Current knowledge, reviewed in this article, suggests that no acute… CONTINUE READING

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