Safety evaluation of toothpaste containing chloroform. II. Long term studies in rats.

  title={Safety evaluation of toothpaste containing chloroform. II. Long term studies in rats.},
  author={Andrea Palmer and A E Street and Francis J. C. Roe and A. N. Worden and N J van Abb{\'e}},
  journal={Journal of environmental pathology and toxicology},
  volume={2 3},
The results of a preliminary rangefinding 13-wk oral toxicity study and of two longer term studies on chloroform in toothpaste base are reported. Significant changes in serum enzymes and certain haemotological parameters were seen at the higher dose-levels in the rangefinding study. Intercurrent disease made it necessary to terminate the first long-term experiment prematurely after 1 yr. No evidence of serious toxicity was recorded. In the second long-term experiment, groups of 50 caesarian… CONTINUE READING


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