Safety evaluation of toothpaste containing chloroform. I. Long-term studies in mice.

@article{Roe1979SafetyEO,
  title={Safety evaluation of toothpaste containing chloroform. I. Long-term studies in mice.},
  author={Francis J. C. Roe and Andrea Palmer and A. N. Worden and N J van Abb{\'e}},
  journal={Journal of environmental pathology and toxicology},
  year={1979},
  volume={2 3},
  pages={799-819}
}
In three experiments, chloroform was administered to mice by gavage in a toothpaste base or in arachis oil, in doses up to 60 mg/kg/d on 6 days/wk for 8 wks. Control groups were left untreated or given vehicle only. In general, there were more survivors in chloroform-treated groups than in the controls. In the case of the males of three strains (C57BL, CBA and CF/1), treatment was associated with no adverse affect on the incidence of any type of neoplasm or any other parameter. In the males but… CONTINUE READING