Safety evaluation of salinomycin in broiler chickens reared in floor pens.

  title={Safety evaluation of salinomycin in broiler chickens reared in floor pens.},
  author={T. Migaki and W. E. Babcock},
  journal={Poultry science},
  volume={58 2},
Salinomycin (Coxistac), a new broad spectrum anticoccidial, was tested in broilers reared in floor pens for safety at 50, 60, 80, 100, and 160 ppm fed continuously from 1 to 56 days of age. Four trials were conducted. Comparisons were made to unmedicated controls and in three trials to monensin to monensin at 80, 100, and 121 ppm. The weight gains at 50 and 60 ppm of salinomycin and 80 and 100 ppm of monensin were statistically comparable and equivalent to or better than controls. The weight… Expand
Evaluation of the efficacy of salinomycin in the control of coccidiosis in chicks.
The weight gain of birds given salinomycin at 80 ppm was depressed significantly (P less than .01) at 56 days as a result of decreased feed consumption, and statistical analysis of main effects on weight gain, feed conversion ratio, hematocrit value, and serum optical density showed no significant differences between sal inomycin, monensin, or halofuginone. Expand
Field trials comparing salinomycin (Coxistac), monensin, and lasalocid in the control of coccidiosis in broilers.
Salinomycin and monensin had equivalent lesion control which was statistically superior (P) and Salinomycin a broad spectrum ionophore anticoccidial was evaluated for toleration and efficacy at 60 ppm in the feed of broiler reared to market weight under floor pen conditions. Expand
Anticoccidial drugs: growth and performance depressing effects in young chickens.
The results of the pair-feeding experiments with 2 to 3 times drug levels indicated that most of the growth depression with medicated diets could be attributed to reduced feed consumption, but all drugs except arprinocid caused some additional growth depression. Expand
Effects on health, performance, and tissue residues of the ionophore antibiotic salinomycin in finishing broilers (21 to 38 d)
The results showed that even at 3 times the prophylactic level, salinomycin does not induce clinical toxicosis or mortality, and a simple method for salInomycin determination in serum is described which can be used as a marker of exposure and/or to predict levels in the diet. Expand
Concentrations of salinomycin in eggs and tissues of laying chickens fed medicated feed for 14 days followed by withdrawal for 3 days.
Recoveries of fortified salinomycin from freeze-dried eggs (albumen and yolk) and tissue, premix and feed were nearly quantitative (> 90%), except liver which was < 85%. Expand
Influence of salinomycin on incidence, shedding, and antimicrobial resistance of Salmonella typhimurium in experimentally infected broiler chicks.
The antibiotic salinomycin appears to be an acceptable feed additive in broilers at the level of 80 g/T based on these results of its effects on salmonellae shedding and antimicrobial resistance. Expand
Effects of various oral doses of salinomycin on serum biochemical parameters in calves
Salinomycin is a monocarboxylic polyether antibiotic with antimicrobial and anticoccidial properties. Although it has proved to be safe at therapeutic doses, toxic effects can result from overdosageExpand
The study presents a median lethal dose (LD50) of sodium salinomycin in Slovak anticoccidial preparation Synvertas and in German anticoccidian preparation Sacox 120 for 4-week-old chickens and the clinical signs of intoxication after lethal doses, which predominated: locomotor ataxia, semiprone or sternal lying position with neck stretched forward and legs stretched backwards. Expand
Influence of salinomycin on antimicrobial resistance of coliforms and streptococci from broiler chickens.
Coliforms from birds fed salinomycin had more (P less than .05) resistance patterns involving two, five, and six drugs and numbers of coliforms resistant to streptomycin, ampicillin, carbenicillin, and cephalothin were greater from birds feeding salinomecin. Expand
Extraction of salinomycin from finished layers ration by microwave solvent extraction followed by liquid chromatography
A rapid, reliable, environmentally friendly and economical extraction technique was developed for the extraction of sodium salinomycin (referred to as salinomycin antibiotic to prevent coccidiosis inExpand


Anticoccidial activity of salinomycin in floor-pen experiments with broilers.
Salinomycin at all treatment levels showed definite anticoccidial activity resulting in improved weights, feed conversion ratios, lesion scores, and mortality compared with unmedicated controls, and in pens with severe coccidiosis, this compound demonstrated a significant improvement in all parameters when compared with the corresponding unmedication controls. Expand
Anticoccidial activity of salinomycin in battery raised broiler chickens.
Evaluated the anticoccidial efficacy of various levels of salinomycin (AHR-3096), a fermentation product of a strain of Streptomyces albus, and the effect on bird performance in uninfected control birds and found it to be statistically as effective as 121 p.p.m. monensin (reference anticoccIDial) in controlling coccidiosis. Expand
The structure of salinomycin, a new member of the polyether antibiotics
Salinomycin' is a new antibiotic elaborated by the strain of Streptomyces aZbus and has an antimicrobial activity against Gram-positive bacteria, mycobacteria and fungi. Furthermore, salinomycin isExpand