Safety evaluation of proanthocyanidin polymer-rich fraction obtained from stem bark of Stryphnodendron adstringens (BARBATIMAO) for use as a pharmacological agent.

@article{Costa2010SafetyEO,
  title={Safety evaluation of proanthocyanidin polymer-rich fraction obtained from stem bark of Stryphnodendron adstringens (BARBATIMAO) for use as a pharmacological agent.},
  author={M. Costa and K. Ishida and V. Kaplum and Eryca Danielle Alves Koslyk and J. C. D. de Mello and T. Ueda-Nakamura and B. P. Dias Filho and C. Nakamura},
  journal={Regulatory toxicology and pharmacology : RTP},
  year={2010},
  volume={58 2},
  pages={
          330-5
        }
}
The widespread use of medicinal plants among the Brazilian population warrants an assessment of the potential risks associated with their intake. Stryphnodendron adstringens (barbatimão) is one of the most frequently used medicinal plants in Brazil, and the risks associated with its use have yet to be investigated. This study evaluated the genotoxic safety of the use of the proanthocyanidin polymer-rich fraction (F2) of stem bark of S. adstringens. The micronucleus test with 750, 1500, and 2250… Expand
Absence of cytotoxic and genotoxic effects of the aqueous extract of Stryphnodendron adstringens ( Barbatimão ) bark using Allium cepa test
10 1 20 23 20 Disponível em http://periodicos.unifap.br/index.php/biota Submetido em 09 de Junho de 2019 / Aceito em 30 de Janeiro de 2020 Biota Amazônia ISSN 2179-5746 Barbatimão [StryphnodendronExpand
Acute and Chronic Toxicity of an Aqueous Fraction of the Stem Bark of Stryphnodendron adstringens (Barbatimão) in Rodents
TLDR
The present results indicate that F2 from the stem bark of S. adstringens caused no toxicity with acute and chronic oral treatment in rodents at the doses administered. Expand
Stryphnodendron adstringens (Mart.) Coville (Fabaceae) proanthocyanidins quantitation by RP-HPLC
Stryphnodendron adstringens (Mart.) Coville (barbatimao) is a tree belonging to the Fabaceae family, and it is commonly found in the southeastern Brazilian cerrado. The stem bark of this tree isExpand
Analysis of In Vitro Cyto- and Genotoxicity of Barbatimão Extract on Human Keratinocytes and Fibroblasts
TLDR
The results suggest that barbatimão could exert genoprotective and antiapoptotic effects on human keratinocytes and fibroblasts. Expand
Evidence of traditionality of Brazilian medicinal plants: The case studies of Stryphnodendron adstringens (Mart.) Coville (barbatimão) barks and Copaifera spp. (copaíba) oleoresin in wound healing.
TLDR
The traditional secular use of barks of barbatimão and oleoresin of copaiba to treat wounds was confirmed based on the historic bibliographic research and can be considered effective in the treatment of wounds. Expand
Healing activity of Stryphnodendron adstringens (Mart.), a Brazilian tannin-rich species: A review of the literature and a case series
TLDR
Considering the difficulty in treating chronic or extensive wounds, barbatimao could be an effective, low-cost phytotherapy formulation with low levels of toxicity. Expand
Proanthocyanidin polymeric tannins from Stryphnodendron adstringens are effective against Candida spp. isolates and for vaginal candidiasis treatment.
TLDR
The data show that proanthocyanidin polymeric tannins obtained from S. adstringens have antifungal activity in vitro against C. albicans and CNA (including fluconazole-resistant isolates) and presented efficacy in the control of candidiasis in murine model, indicating potential use in the treatment of vaginal candidiasis. Expand
Stryphnodendron Species Known as “Barbatimão”: A Comprehensive Report
TLDR
The aim of the present study was to highlight the importance of S. adstringens, as well as other Stryphnodendron species recognized as “barbatimão”, to human health, depicting the relevance of ethnopharmacological knowledge to scientific evidence for uses, related chemical compounds, development of pharmaceutical formulations, and the establishment of toxicity parameters. Expand
Potential of Total Polyphenols from Barbatimão against Different Reactive Oxygen/Nitrogen Species
The objective of this study was to obtain the polyphenol fraction from Stryphnodendron adstringens (Mart.) Coville (Barbatimão) and evaluate their potential effect against different reactiveExpand
Pharmaceutical topical gel containing proanthocyanidin polymers-rich fraction from Stryphnodendron adstringens
TLDR
A pharmaceutical topical gel containing a proanthocyanidin polymers-rich fraction for use as a pharmacological agent in vaginal gels is proposed and validation parameters for the determination of phenolic compounds are evaluated. Expand
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Absence of genotoxicity of a phytotherapeutic extract from Stryphnodendron adstringens (Mart.) Coville in somatic and germ cells of Drosophila melanogaster
TLDR
The results of the experiments suggest that the phytotherapeutic extract from S. adstringens stem bark is not genotoxic in somatic and germ cells of D. melanogaster. Expand
Efeito Modulador do Extrato de Stryphnodendron adstringens Mart. (Barbatimão) Contra Danos Induzidos pela Mitomicina C em Camundongos
TLDR
The obtained results showed no significantly inhibition of MNPCE, and the antigenotoxicity effect of ethanolic extract of barbatimao (EEB) against induced damage by mitomycin C (MMC) by the bone marrow micronucleus test in mice was evaluated. Expand
Assessment of the mutagenic, antimutagenic and cytotoxic activities of ethanolic extract of araticum (Annona crassiflora Mart. 1841) by micronucleus test in mice.
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Results indicate an antimutagenic activity of the EEA, which is widely used in humans as therapeutic medicine to treat several diseases such as diarrhea, rheumatism and syphilis. Expand
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The extract made with T. indica was devoid of clastogenic and genotoxic activities in the cells of the rodents, when administered orally at these three acute doses. Expand
Activity of tannins from Stryphnodendron adstringens on Cryptococcus neoformans: effects on growth, capsule size and pigmentation
TLDR
The data indicate that tannins extracted from S. adstringens interfered with growth, capsule size and pigmentation, all important virulence factors of C. neoformans, and may be considered as a putative candidate for the development of new antifungal agents. Expand
Biological effects of extracts obtained from Stryphnodendron adstringens on Herpetomonas samuelpessoai.
TLDR
The effect of Stryphnodendron adstringens on the trypanosomatid Herpetomonas samuelpessoai is reported and considerable ultrastructural alterations, such as marked mitochondrial swelling with a large number of cristae and evident Golgi complex vesiculation, are observed by transmission electron microscopy. Expand
Genotoxicity study of Hypiran and Chamomilla herbal drugs determined by in vivo supervital micronucleus assay with mouse peripheral reticulocytes.
TLDR
Maximum Tolerated Dose (MTD) was obtained according to CSGMT protocol presented by the Environmental Mutagen Society of Japan and Chamomilla herbal drog can be classified as equivocul category of genot toxicity and Hypiran did not show genotoxicity. Expand
Influence of tannins from Stryphnodendron adstringens on growth and virulence factors of Candida albicans.
TLDR
Investigation of the antifungal activity of a crude extract, fractions and subfractions from Stryphnodendron adstringens (Mart.) Coville showed 'Barbatimão' extracts showed low cytotoxicity to Vero cells, macrophages and red blood cells, which justifies further studies to investigate the mechanisms of action and the possible development of a new antIFungal agent. Expand
Experimental evaluation of stem bark of Stryphnodendron adstringens (Mart.) Coville for antiinflammatory activity
TLDR
The acetone soluble fraction from the crude extract of Stryphnodendron adstringens stem bark was evaluated in acute and chronic models of inflammation and significantly decreased the vascular permeability increase caused by intraperitoneal acetic acid in mice. Expand
Evaluation of the in vitro and in vivo genotoxicity of magnolia bark extract.
TLDR
The results of these studies demonstrate that MBE is not genotoxic under the conditions of the in vitro bacterial reverse mutation assay and the in vivo micronucleus test, and support the safety of MBE for dietary consumption. Expand
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