Safety evaluation of mulberry leaf extract: Acute, subacute toxicity and genotoxicity studies

  title={Safety evaluation of mulberry leaf extract: Acute, subacute toxicity and genotoxicity studies},
  author={Yuzhe Li and Xiaopeng Zhang and Chunlai Liang and Jing Hu and Zhou Yu},
  journal={Regulatory Toxicology and Pharmacology},

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[Ninety-day dietary toxicity study of mulberry leaf extract in rats].

Findings indicate that dietary intake of 1% mulberry leaf extract for 90 days (884.5 mg/kg/day for males and 995.7 mg/ kg/ day for females as mean daily intake) causes no toxicological change in rats.

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In vivo results showed that mulberry leaf extract is a potent protector against glyphosate-induced toxicity, and its protective effect could result from synergism or antagonism between the various bioactive phenolic compounds in the acetonic fraction from M. alba leaf extract.

Prevention Effects and Possible Molecular Mechanism of Mulberry Leaf Extract and its Formulation on Rats with Insulin-Insensitivity

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The increase in glucose uptake was a mechanism of hypoglycemic actions by W and A2 of Folium Mori.

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