Safety evaluation of desloratadine in allergic rhinitis

@article{GonzlezNez2013SafetyEO,
  title={Safety evaluation of desloratadine in allergic rhinitis},
  author={Vanesa Gonz{\'a}lez-N{\'u}{\~n}ez and Antonio Lu{\'i}s Valero and Joaquim Mullol},
  journal={Expert Opinion on Drug Safety},
  year={2013},
  volume={12},
  pages={445 - 453}
}
Introduction: Desloratadine is a biologically active metabolite of second-generation antihistamine loratadine. It is also indicated for the treatment of allergic diseases, including allergic rhinitis. Areas covered: A Medline search was conducted to identify preclinical and clinical studies of desloratadine. This was supplemented with additional articles obtained from online sources. The focus of this review is on the safety profile of desloratadine. Expert opinion: The review of these data… 

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Statistical study on the incidence of allergic diseases treated with desloratadine and levocetirizine at "Atopia" Allergology Medical Center, Iaşi, Romania.

The most common allergic diseases treated with desloratadine or levocetirizine, second-generation antihistamines were urticaria, allergic rhinoconjunctivitis, allergic bronchitis, and allergic asthma.

The role of endothelin-1 and endothelin receptor antagonists in allergic rhinitis inflammation: ovalbumin-induced rat model.

ET-1 is one of the mediators that impact AR development and ET-1 antagonists can be useful for symptom control and for decreasing allergic inflammation in AR patients.

Brain histamine H1 receptor occupancy after oral administration of desloratadine and loratadine

At therapeutic doses, desloratadine did not bind significantly to brain H1Rs and did not induce any significant sedation, and subjective sleepiness did not significantly differ among subjects receiving the two antihistamines and placebo.

Characterization of the chloroquine‐induced mouse model of pruritus using an automated behavioural system

The use of an automated integrated behavioural assessment in CQ‐induced pruritus makes the assay suitable for screening purposes and allows for a correct interpretation of the antipruritic effect of the compounds evaluated.

Desloratadine Exposure and Incidence of Seizure: A Nordic Post-authorization Safety Study Using a New-User Cohort Study Design, 2001–2015

This study found an increased incidence rate of seizure during DL exposed periods as compared to unexposed periods among individuals younger than 20 years, and no difference in incidence Rate of seizure was observed in adults between DL exposed and unexposed.

Pharmacokinetics and Tissue Distribution of Loratadine, Desloratadine and Their Active Metabolites in Rat based on a Newly Developed LC-MS/MS Analytical Method.

The tissue distribution study shows that LOR, DL and their active metabolites were widely distributed in the liver, spleen, thymus, heart, adrenal glands and pituitary gland, suggesting that Loratadine may have a greater tendency to distribute in the heart than its metabolites.

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