Safety evaluation of Evesse EPC, an apple polyphenol extract rich in flavan-3-ols.

@article{Lina2012SafetyEO,
  title={Safety evaluation of Evesse EPC, an apple polyphenol extract rich in flavan-3-ols.},
  author={Ben A R Lina and Astrid A. Reus and Oliver Hasselwander and Quynh Bui and Paul Tenning},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={2012},
  volume={50 8},
  pages={2845-53}
}
The safety of the apple polyphenol extract EvesseEPC, which is rich in flavan-3-ols, particularly epicatechin, was evaluated. Both in a bacterial reverse mutation test and a mouse lymphoma assay, EvesseEPC showed a positive response in vitro. In vivo studies (UDS test in hepatocytes, bone marrow micronucleus test and comet assay in intestinal cells) were… CONTINUE READING