Safety evaluation and risk assessment of the herbicide Roundup and its active ingredient, glyphosate, for humans.

  title={Safety evaluation and risk assessment of the herbicide Roundup and its active ingredient, glyphosate, for humans.},
  author={G. M. Williams and Robert Kroes and I. C. Munro},
  journal={Regulatory toxicology and pharmacology : RTP},
  volume={31 2 Pt 1},
Reviews on the safety of glyphosate and Roundup herbicide that have been conducted by several regulatory agencies and scientific institutions worldwide have concluded that there is no indication of any human health concern. [] Key Method It includes assessments of glyphosate, its major breakdown product [aminomethylphosphonic acid (AMPA)], its Roundup formulations, and the predominant surfactant [polyethoxylated tallow amine (POEA)] used in Roundup formulations worldwide.
Evaluation of carcinogenic potential of the herbicide glyphosate, drawing on tumor incidence data from fourteen chronic/carcinogenicity rodent studies
The lack of a plausible mechanism, along with published epidemiology studies which fail to demonstrate clear, statistically significant, unbiased and non-confounded associations between glyphosate and cancer of any single etiology, support the conclusion that glyphosate does not present concern with respect to carcinogenic potential in humans.
Potential toxic effects of glyphosate and its commercial formulations below regulatory limits.
Glyphosate toxicity and carcinogenicity: a review of the scientific basis of the European Union assessment and its differences with IARC
The scientific basis of the glyphosate health assessment conducted within the European Union (EU) renewal process is presented, and the differences in the carcinogenicity assessment with IARC are explained.
Glyphosate: environmental contamination, toxicity and potential risks to human health via food contamination
  • S. Bai, S. Ogbourne
  • Environmental Science
    Environmental Science and Pollution Research
  • 2016
Assessment of the health risks associated with glyphosate are more complicated than suggested by acute toxicity data that relate primarily to accidental high-rate exposure.
The impact and toxicity of glyphosate and glyphosate-based herbicides on health and immunity
Evidence points to a need for more studies to better decipher the risks from glyphosate and better regulation of its global utilization, as increasing evidence shows that glyphosate and glyphosate-based herbicides exhibit cytotoxic and genotoxic effects.
Developmental and Reproductive Outcomes in Humans and Animals After Glyphosate Exposure: A Critical Analysis
The available literature shows no solid evidence linking glyphosate exposure to adverse developmental or reproductive effects at environmentally realistic exposure concentrations, and suggests that such effects were due to surfactants present in the formulations and not the direct result of glyphosate exposure.


Genotoxic Activity of Glyphosate and Its Technical Formulation Roundup
The formulated commercial product, Roundup, and its active agent, glyphosate, were tested in the same battery of assays for the induction of DNA damage and chromosomal effects in vivo and in vitro and revealed a weak activity of the technical formulation.
Adequacy of required regulatory hazard testing for the detection of potential hormonal activity of crop protection chemicals.
Evidence is presented that demonstrates that the regulatory safety assessment paradigm has a low likelihood of missing potential endocrine-active chemicals and has served society well.
FIFRA Subdivision F testing Guidelines: are these tests adequate to detect potential hormonal activity for crop protection chemicals? Federal Insecticide, Fungicide, and Rodenticide Act.
The review presented herein concentrates on the required Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) testing for pesticides, and demonstrates how the massive arrays of sensitive endocrine endpoints that are delineated in FIFRA Subdivision F have been successfully used to detect both weak and potent hormonally modulating chemicals.
Acute toxicity of combinations of pesticides.
The oral and intratracheal toxicities of ROUNDUP and its components to rats.
POEA and preparations that contained POEA were more toxic than glyphosate, and both POEA and glyphosate caused lung hemorrhages and lung epithelial cell damage with po or intratracheal exposures.
Glyphosate skin binding, absorption, residual tissue distribution, and skin decontamination.
Glyphosate is a broad-spectrum postemergence translocated herbicide. Its interactions with skin and potential systemic availability through percutaneous absorption was studied by skin binding, skin
Acute Poisoning with a Glyphosate-Surfactant Herbicide ('Roundup'): A Review of 93 Cases
There were seven deaths following ingestion of 'Roundup' alone, due to a syndrome that involved hypotension, unresponsive to intravenous fluids or vasopressor drugs, and sometimes pulmonary oedema, in the presence of normal central venous pressure.
An evaluation of the genotoxic potential of glyphosate.
  • A. Li, T. Long
  • Biology
    Fundamental and applied toxicology : official journal of the Society of Toxicology
  • 1988
The potential genotoxicity of glyphosate, the active ingredient in Roundup herbicide, was tested in a variety of well-established in vitro and in vivo assays including the Salmonella typhimurium and