Safety criteria for transcranial direct current stimulation (tDCS) in humans

  title={Safety criteria for transcranial direct current stimulation (tDCS) in humans},
  author={Michael A. Nitsche and David Liebetanz and Nicolas Lang and Andrea Antal and Frithjof Tergau and Walter Paulus},
  journal={Clinical Neurophysiology},

Cerebellar contributions to nonmotor behaviour

Phase-IIa randomized, double-blind, sham-controlled, parallel group trial on anodal transcranial direct current stimulation (tDCS) over the left and right tempo-parietal junction in autism spectrum disorder—StimAT: study protocol for a clinical trial

If shown, positive results regarding change in parent-rated social cognition and favourable safety and tolerability of the intervention will confirm tDCS as a promising treatment for ASD core-symptoms may be a first step in establishing a new and cost-efficient intervention for individuals with ASD.

Modulation of Brain Activity with Noninvasive Transcranial Direct Current Stimulation (tDCS): Clinical Applications and Safety Concerns

This review covers the typical characteristics and the underlying neural mechanisms of tDCS treatment in clinical samples including people with drug addiction, major depression disorder, Alzheimer's disease, as well as in children and future research directions are discussed.

tDCS for Memory Enhancement: Analysis of the Speculative Aspects of Ethical Issues

It is concluded that ethical discussion about memory enhancement via tDCS sometimes involves undue speculation, and closer attention to scientific and social facts would bring a more nuanced analysis.

Neural control of the proximal upper limb: Implications for recovery after stroke

This book aims to provide a history of web exceptionalism from 1989 to 2002, a period chosen in order to explore its roots as well as specific cases up to and including the year in which descriptions of “Web 2.0” began to circulate.

Inducing Neuroplastic Changes in the Human Cortex using External Transcranial Electrical Stimulation Techniques

This thesis presents studies evaluating the role of novel transcranial electrical stimulation techniques and their methodological approaches, and explores the application of these novel methods of inducing neuroplastic aftereffects, their impact upon targeted neural networks and how long these afterffects can be sustained.



Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation

Transcranial electrical stimulation using weak current may be a promising tool to modulate cerebral excitability in a non‐invasive, painless, reversible, selective and focal way.

Current Distribution in the Brain From Surface Electrodes

It is apparent that the amount and distribution of current entering the brain is of great consequence, yet the literature discloses no systematic mathematical or experimental method for predicting current flow.

Histological evaluation of neural damage from electrical stimulation: considerations for the selection of parameters for clinical application.

Recommendations have been made for the selection of electrical stimulus parameters to be used in central nervous system prostheses based on the relationship of charge density per phase and total charge to neural damage investigated after surface stimulation of the parietal cortex in normal cats.

External modulation of visual perception in humans

The results show that primary visual functions, such as contrast detection can be transiently altered by transcranial weak direct current stimulation, most probably modulating neural excitability, as has been shown in the motor cortex previously.

Considerations for safety in the use of extracranial stimulation for motor evoked potentials.

Data indicate that the charge per phase used in most of the extracranial MEP protocols is sufficient to induce neural damage if the stimulation is applied continuously for several hours, and that low resistance paths between the stimulating electrode and the brain may give rise to foci of high charge density.