Safety considerations with omega-3 fatty acid therapy.

  title={Safety considerations with omega-3 fatty acid therapy.},
  author={Harold Edward Bays},
  journal={The American journal of cardiology},
  volume={99 6A},
  • H. Bays
  • Published 19 March 2007
  • Biology
  • The American journal of cardiology

Prescription omega-3 fatty acids and their lipid effects: physiologic mechanisms of action and clinical implications

Mechanistically, most evidence suggests that omega-3 fatty acids reduce the synthesis and secretion of very-low-density lipoprotein (VLDL) particles, and increase TG removal from VLDL and chylomicron particles through the upregulation of enzymes, such aslipoprotein lipase.

Overview of omega-3 Fatty Acid therapies.

The REDUCE-IT study is being conducted to evaluate the effect of the combination of IPE and statins on cardiovascular outcomes in high-risk patients.

DHA derivatives of fish oil as dietary supplements: a nutrition-based drug discovery approach for therapies to prevent metabolic cardiotoxicity

This review summarizes the current knowledge on the distinct effects of EPA and DHA to prevent metabolic syndrome and reduce cardiotoxicity risk and focuses on using nutrition-based drug discovery to explore the potential of DHA derivatives for the treatment of obesity, metabolic Syndrome and cardiovascular diseases.

Potential Effects of Omega-3 Fatty Acid Supplements in the Prevention of Type 2 Diabetes: A Critical Appraisal of Data from Randomized Clinical Trials

Overall, the evidence for the beneficial or deleterious effects of fish oil supplements on insulin sensitivity has been inconsistent, with limited randomized trial data involving small trials of short duration.

Omega-3 fatty acids and cardiovascular disease: epidemiology and effects on cardiometabolic risk factors.

Omega-3 fatty acids benefit multiple cardiometabolic risk factors including lipids, blood pressure, vascular reactivity and cardiac function, as well as having antithrombotic, anti-inflammatory and anti-oxidative actions.

The role of omega-3 polyunsaturated fatty acid supplementation in the management of type 2 diabetes mellitus

Omega-3 PUFA supplementation is generally well-tolerated and does not appear to be contraindicated for patients on anticoagulant therapy; however, uncertainty persists regarding the purity and stability of commercial omega-3PUFA products.

Prescription omega-3 fatty acid products: considerations for patients with diabetes mellitus

Ongoing studies of the effects of prescription OM3FAs on cardiovascular outcomes will help determine whether these products will emerge as effective add-on options to statin therapy for reduction of residual cardiovascular disease risk.

The Effects of Fish Oil on Cardiovascular Diseases: Systematical Evaluation and Recent Advance

An updated systematical review is performed in order to provide a contemporary understanding with regard to the effects of fish oil on cardiovascular diseases.

Perspectives on a new prescription omega-3 fatty acid, icosapent ethyl, for hypertriglyceridemia

A large ongoing outcomes trial will assess the efficacy of IPE in preventing cardiovascular events in high-risk, statin-treated patients with hypertriglyceridemia, and IPE may offer benefits over other dyslipidemia treatment options.



Evidence for the Cardioprotective Effects of Omega-3 Fatty Acids

OBJECTIVE: To review available literature regarding the cardiovascular effects of marine-derived ω-3 fatty acids and evaluate the benefit of these fatty acids in the prevention of coronary heart

Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease.

Recommendations reflecting the current state of knowledge will be made with regard to both fish consumption and omega-3 fatty acid (plant- and marine-derived) supplementation in the context of recent guidance issued by the US Environmental Protection Agency and the Food and Drug Administration about the presence of environmental contaminants in certain species of fish.

Effects of omega-3 fatty acids on cardiovascular risk factors and intermediate markers of cardiovascular disease.

For outcomes with few studies, all studies were included regardless of study design or sample size (minimum of five subjects), and for most outcomes of interest, analysis was confined to the largest randomized trials for each outcome evaluated.

Effects of Marine Fish Oils on the Anticoagulation Status of Patients Receiving Chronic Warfarin Therapy

Fish oil supplementation in doses of 3–6 grams per day does not seem to create a statistically significant effect on the anticoagulation status of patients receiving chronic warfarin therapy.


Omega-3 fatty acids have been shown to significantly reduce the risk for sudden death caused by cardiac arrhythmias and all-cause mortality in patients with known coronary heart disease and are used to treat hyperlipidemia, hypertension, and rheumatoid arthritis.

Impact of n-3 fatty acid supplemented parenteral nutrition on haemostasis patterns after major abdominal surgery

It is suggested that infusion of fish oil in doses up to 0.2 g/kgBW per day is safe regarding coagulation and platelet function, as indicated in a prospective, randomised, double blinded clinical trial conducted in two operative intensive care units.

Measurement of organochlorines in commercial over-the-counter fish oil preparations: implications for dietary and therapeutic recommendations for omega-3 fatty acids and a review of the literature.

Fish oil supplements are more healthful than the consumption of fish high in organochlorines, and provide the benefits of omega-3 fatty acids without the risk of toxicity.

Fish intake, contaminants, and human health: evaluating the risks and the benefits.

For major health outcomes among adults, the benefits of fish intake exceed the potential risks, and for women of childbearing age, benefits of modest fish intake, excepting a few selected species, also outweigh risks.

Fish Oil, Atherogenesis, and Thrombogenesis a

In swine, it is observed that monocyte adhesions and platelet clumps over the lesion surface of proximal left anterior descending (LAD) coronary arteries are markedly reduced when an atherogenic diet was supplemented with cod-liver oil, even when the cholesterol levels were equalized with the untreated group, suggesting that fish oil is hypothrombogenic.