Safety considerations for nucleic acid vaccines.

@article{Robertson1994SafetyCF,
  title={Safety considerations for nucleic acid vaccines.},
  author={J. Ian S. Robertson},
  journal={Vaccine},
  year={1994},
  volume={12 16},
  pages={
          1526-8
        }
}
Whilst it is premature to formulate guidelines for the manufacturing requirements of a nucleic acid vaccine, it can never be too early to discuss and debate the issues surrounding the use of a novel biotherapeutic. The major safety issues posed by nucleic acid vaccination include the possibility of transformation (or tumorigenic) events in recipients of a DNA vaccine, the potential formation of anti-DNA antibodies, and unexpected and untoward effects of long-term expression of a foreign antigen… CONTINUE READING