Safety concerns for the potential use of cyanovirin-N as a microbicidal anti-HIV agent.

@article{Huskens2008SafetyCF,
  title={Safety concerns for the potential use of cyanovirin-N as a microbicidal anti-HIV agent.},
  author={Dana Huskens and Kurt Vermeire and Elise L. Vandemeulebroucke and Jan Balzarini and Dominique Schols},
  journal={The international journal of biochemistry & cell biology},
  year={2008},
  volume={40 12},
  pages={2802-14}
}
Based on its antiviral activity profile, cyanovirin-N (CV-N) holds great potential for anti-HIV microbicidal application. However, limited data are available on the possible side-effects of this lectin. A detailed investigation was carried out to obtain better insights in the cytotoxic, inflammatory and (anti)-proliferative properties of CV-N in comparison with several other plant-derived lectins. CV-N affected the cell morphology of PBMCs and enhanced the expression of the cellular activation… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 33 extracted citations

Functional Contributions of Carbohydrate on AIDS Virus Glycoprotein

The Yale journal of biology and medicine • 2010
View 5 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…