Safety assessment on polyethylene glycols (PEGs) and their derivatives as used in cosmetic products.

@article{FruijtierPlloth2005SafetyAO,
  title={Safety assessment on polyethylene glycols (PEGs) and their derivatives as used in cosmetic products.},
  author={Claudia Fruijtier-P{\"o}lloth},
  journal={Toxicology},
  year={2005},
  volume={214 1-2},
  pages={
          1-38
        }
}

Tables from this paper

Safety Evaluation of Polyethylene Glycol (PEG) Compounds for Cosmetic Use
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Standardization of the terminology used to describe the presence of PEGs in products would help patients to identify them clearly and unequivocally and thus avoid the development of hypersensitivity reactions.
An Investigation of the Influence of PEG 400 and PEG-6-Caprylic/Capric Glycerides on Dermal Delivery of Niacinamide
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The findings suggest that PEG 400 may be a useful component of formulations for the delivery of actives to the skin rather than through the skin, especially when combined with other solvents.
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The doses used clinically for current and many future PEGylated biologicals are low and will result in exposures to PEG significantly lower than that required to elicit PEG toxicity.
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How the prevalence of P EG in everyday products has induced αPEG Abs within the general public as well as the effect of these Abs on the performance of PEGylated therapeutics are reviewed.
Safety assessment of alkyl PEG ethers as used in cosmetics.
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The CIR Expert Panel concluded that the Alkyl PEG ethers are safe as used when formulated to be nonirritating, and the same applies to future alkylPEG ether cosmetic ingredients that vary from those ingredients recited herein only by the number of ethylene glycol repeat units.
Immediate‐type hypersensitivity to polyethylene glycols: a review
  • E. Wenande, L. Garvey
  • Medicine
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • 2016
TLDR
This first comprehensive review provides practical information for allergists and other healthcare professionals by describing the clinical picture of 37 reported cases of P EG hypersensitivity since 1977, summarizing instances where PEG hypersensitivity should be considered and proposing an algorithm for diagnostic management.
PEGylated Proteins: Evaluation of Their Safety in the Absence of Definitive Metabolism Studies
TLDR
Assuming that toxicological evaluation of a biological molecule of interest is complete and satisfactory therapeutic windows are achieved, the data contained in this review indicate that the PEG associated with a protein or other biological molecule does not represent an additional unquantified risk to humans.
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