Safety assessment of the calcium-binding protein, apoaequorin, expressed by Escherichia coli.

  title={Safety assessment of the calcium-binding protein, apoaequorin, expressed by Escherichia coli.},
  author={Daniel L Moran and Afua O Tetteh and Richard E. Goodman and Mark Y. Underwood},
  journal={Regulatory toxicology and pharmacology : RTP},
  volume={69 2},

Subchronic toxicity of lyophilized apoaequorin protein powder in Sprague-Dawley rats

The no-observed-adverse-effect-level (NOAEL) of lyophilized apoaequorin protein powder (LAPP) was 4000 mg/kg/day, the highest dose tested in male and female rats, considered to be of little toxicological significance.

Food safety assessment of Cry8Ka5 mutant protein using Cry1Ac as a control Bt protein.

  • D. FariasM. P. Viana A. F. Carvalho
  • Biology, Medicine
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2015

Bioactive Compounds of Nutraceutical Value from Fishery and Aquaculture Discards

The possible valorisation of seafood and their by-products are focused on, which represent a source of biomolecules, useful for the sustainable production of high-value nutraceutical compounds in the authors' circular economy era.

Nutraceuticals for Cognitive Dysfunction

Various nutraceuticals and substances that have potential to improve cognition and memory in senior dogs and cats are described.

Bad Science: Exploring the unethical research behind a putative memory supplement

Students who successfully complete the lesson know criteria for evaluating the quality of material that is presented as scientific and feel empowered to make informed decisions about health and wellness based on their newly acquired practice with identifying valid/invalid scientific reasoning and with recognizing pseudoscience.



Calcium-binding proteins: basic concepts and clinical implications.

  • C. Heizmann
  • Biology
    General physiology and biophysics
  • 1992
Another protein family are the annexins, members of which interact with phospholipids and cellular membranes in a calcium-dependent manner, and in some cases members of the annexin family were even found to interact with EF-hand proteins.

Calcium-binding proteins.

Safety assessment of Apoaequorin, a protein preparation: subchronic toxicity study in rats.

Measurement of cytosolic free calcium in mammalian cells with aequorin.

Evidence is presented that the aequorin-Ca light signal originates in the cytosol and that the cells subjected to the HOST procedure have a normal viability and functional integrity with respect to growth, respiration, membrane transport calcium metabolism, and hormone responsiveness.

Stability of food allergens to digestion in vitro

The data are consistent with the hypothesis that food allergens must exhibit sufficient gastric stability to reach the intestinal mucosa where absorption and sensitization can occur, and indicate the stability to digestion is a significant and valid parameter that distinguishes food allergen from nonallergens.

Crystal Structure of a Ca2+-discharged Photoprotein

The crystal structure of the Ca2+-discharged photoprotein obelin is reported and a significant repositioning and flipping of the His-175 imidazole ring as crucially required in the trigger hypothesis are lent support to the proposed mechanisms and provide new structural insight into details of these processes.

Suggested Improvements for the Allergenicity Assessment of Genetically Modified Plants Used in Foods

Current practices and new regulatory demands related to food safety are discussed, including potential increases in the allergenicity, toxicity, and nutrient availability of foods derived from the GM plants.

Epitope mapping of the major allergen from Atlantic cod in Spanish population reveals different IgE-binding patterns.

A relevant antigenic region in parvalbumin from Atlantic cod (Gad m 1), the most consumed cod species in Spain, is identified and could be considered as a severity marker and provides additional information to improve fish allergy diagnosis and the design of safe immunotherapeutic tools.