Safety assessment of intensive induction therapy in childhood anaplastic large cell lymphoma: report of the ALCL99 randomised trial.

@article{Wrobel2011SafetyAO,
  title={Safety assessment of intensive induction therapy in childhood anaplastic large cell lymphoma: report of the ALCL99 randomised trial.},
  author={G. T. Wrobel and Audrey Mauguen and Angelo Rosolen and A. Reiter and Denise Mary Williams and Keizo Horibe and Laurence Brugi{\`e}res and Marie-C{\'e}cile le Deley},
  journal={Pediatric blood & cancer},
  year={2011},
  volume={56 7},
  pages={1071-7}
}
BACKGROUND ALCL99 protocol including six courses of chemotherapy derived from the NHL-BFM protocol is widely used for the treatment of paediatric anaplastic large-cell lymphoma. In the ALCL99 trial, patients were randomised to receive MTX 1 g/m² in 24 hr with intrathecal injection (MTX1) versus MTX 3 g/m² in 3 hr without intrathecal (MTX3); then to receive or not vinblastine (high-risk patients). The present study provides information about the acute adverse reactions (ARs) during the six… CONTINUE READING

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