Safety aspects in the manufacturing of plasma-derived coagulation factor concentrates.

  • Thierry Burnouf
  • Published 1992 in
    Biologicals : journal of the International…


Plasma-derived coagulation factor concentrates, prepared using traditional manufacturing processes, have transmitted viral diseases, especially AIDS, hepatitis B and hepatitis C to patients. To date, more extensive selection of blood donors, improved screening procedures of each plasma donation for direct and indirect viral markers, and newly developed… (More)