Safety and tolerability of plecanatide in patients with chronic idiopathic constipation: long-term evidence from an open-label study.


OBJECTIVE This multi-center, fixed-dose, open-label study evaluated the long-term safety and tolerability of once-daily oral plecanatide for the treatment of adults with chronic idiopathic constipation (CIC). METHODS Eligible patients completed a phase 2b or phase 3 double-blind study of plecanatide, or had not previously been treated with plecanatide… (More)
DOI: 10.1080/03007995.2018.1430024


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