Safety and tolerability of lamotrigine: results from 12 placebo-controlled clinical trials and clinical implications.

Abstract

The mechanism of action of lamotrigine depends on voltage-sensitive sodium channels by which the neuronal membrane is stabilized and the release of excitatory neurotransmitters, such as glutamate and aspartate, is inhibited. Lamotrigine is indicated for maintenance treatment of bipolar I disorder to delay the time to the occurrence of mood episodes for… (More)
DOI: 10.1097/WNF.0b013e3182055c07

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@article{Seo2011SafetyAT, title={Safety and tolerability of lamotrigine: results from 12 placebo-controlled clinical trials and clinical implications.}, author={Ho-Jun Seo and A. Della Chiesa and Soo-Jung Lee and Ashwin A. Patkar and Changsu Han and Prakash S. Masand and Alessandro Serretti and Chi-Un Pae}, journal={Clinical neuropharmacology}, year={2011}, volume={34 1}, pages={39-47} }