Safety and tolerability of cyclosporin a in severe traumatic brain injury patients: results from a prospective randomized trial.

@article{Mazzeo2009SafetyAT,
  title={Safety and tolerability of cyclosporin a in severe traumatic brain injury patients: results from a prospective randomized trial.},
  author={Anna Teresa Mazzeo and Gretchen M. Brophy and Charlotte B. Gilman and {\'O}scar Lu{\'i}s Alves and Jaime R. Robles and Ronald L. Hayes and John Theodore Povlishock and Malcolm Ross Bullock},
  journal={Journal of neurotrauma},
  year={2009},
  volume={26 12},
  pages={2195-206}
}
Cyclosporin A (CsA) has recently been proposed for use in the early phase after traumatic brain injury (TBI), for its ability to preserve mitochondrial integrity in experimental brain injury models, and thereby provide improved behavioral outcomes as well as significant histological protection. The aim of this prospective, randomized, double-blind, dual-center, placebo-controlled trial was to evaluate the safety, tolerability, and pharmacokinetics of a single intravenous infusion of CsA in… CONTINUE READING
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