Corpus ID: 12872687

Safety and pharmacokinetic study with escalating doses of 3-acetyl-7-oxo-dehydroepiandrosterone in healthy male volunteers.

@article{Davidson2000SafetyAP,
  title={Safety and pharmacokinetic study with escalating doses of 3-acetyl-7-oxo-dehydroepiandrosterone in healthy male volunteers.},
  author={M. Davidson and Amit Kumar Marwah and R. Sawchuk and K. Maki and P. Marwah and C. Weeks and H. Lardy},
  journal={Clinical and investigative medicine. Medecine clinique et experimentale},
  year={2000},
  volume={23 5},
  pages={
          300-10
        }
}
OBJECTIVES To evaluate the safety and pharmacokinetics of 3-acetyl-7-oxo-DHEA (3beta-acetoxyandrost-5-ene-7,17-dione) given orally. DESIGN A randomized, double blind, placebo-controlled, escalating dose study. SETTING The Chicago Center for Clinical Research. PARTICIPANTS Twenty-two healthy men. STUDY METHOD The participants received placebo (n = 6) or 3-acetyl-7-oxo-DHEA (n = 16) at 50 mg/d for 7 days followed by a 7-day washout; 100 mg/d for 7 days followed by a 7-day washout; and 200… Expand
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