Safety and pharmacokinetic profiles of phosphorodiamidate morpholino oligomers with activity against ebola virus and marburg virus: results of two single-ascending-dose studies.

Abstract

Two identical single-ascending-dose studies evaluated the safety and pharmacokinetics (PK) of AVI-6002 and AVI-6003, two experimental combinations of phosphorodiamidate morpholino oligomers with positive charges (PMOplus) that target viral mRNA encoding Ebola virus and Marburg virus proteins, respectively. Both AVI-6002 and AVI-6003 were found to suppress… (More)
DOI: 10.1128/AAC.03442-14

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@article{Heald2014SafetyAP, title={Safety and pharmacokinetic profiles of phosphorodiamidate morpholino oligomers with activity against ebola virus and marburg virus: results of two single-ascending-dose studies.}, author={Alison E. Heald and Patrick L. Iversen and Jay B Saoud and Peter L. Sazani and Jay S. Charleston and Tim Axtelle and Michael T. Wong and William Bernard Smith and Apinya Bee Vutikullird and Edward M. Kaye}, journal={Antimicrobial agents and chemotherapy}, year={2014}, volume={58 11}, pages={6639-47} }