Safety and immunological outcomes following human inoculation with nontypeable Haemophilus influenzae.

  title={Safety and immunological outcomes following human inoculation with nontypeable Haemophilus influenzae.},
  author={Patricia L. Winokur and Kathryn Chaloner and Gary V. Doern and Jennifer Ferreira and Michael A. Apicella},
  journal={The Journal of infectious diseases},
  volume={208 5},
BACKGROUND Nontypeable Haemophilus influenzae (NTHi) exclusively infects humans, causing significant numbers of upper respiratory tract infections. The goal of this study was to develop a safe experimental human model of NTHi nasopharyngeal colonization. METHODS A novel streptomycin-resistant strain of NTHi was developed, and 15 subjects were inoculated in an adaptive-design phase I trial to rapidly identify colonizing doses of NTHi. Bayesian analysis was used to estimate the human colonizing… CONTINUE READING
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