Safety and immunogenicity of heptavalent pneumococcal CRM197 conjugate vaccine in infants and toddlers.

@article{Shinefield1999SafetyAI,
  title={Safety and immunogenicity of heptavalent pneumococcal CRM197 conjugate vaccine in infants and toddlers.},
  author={Henry R. Shinefield and Sb Black and Paula J Ray and Ih Seop Chang and Ned Lewis and Bruce Fireman and Jill G. Hackell and Peter R. Paradiso and George Siber and Robert C. Kohberger and D Viceps Madore and F. J. Malinowski and Akira Kimura and Chinh Le and I Landaw and Jaime Orteg{\'o}n Aguilar and Jb Hansen},
  journal={The Pediatric infectious disease journal},
  year={1999},
  volume={18 9},
  pages={
          757-63
        }
}
OBJECTIVES The objectives of this study were (1) to determine the safety and immunogenicity of heptavalent pneumococcal CRM197 conjugate (PNCRM7) vaccine in infants and (2) to determine the effect of concurrent hepatitis B immunization during the primary series and the effect of concurrent diphtheria and tetanus toxoid and acellular pertussis [DTaP (ACEL-IMUNE)] and conjugate CRM197 Haemophilus influenzae type b [HbOC (HibTITER) immunization at time of the booster dose on the safety and… CONTINUE READING
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