Safety and immunogenicity of an HIV subtype B and E prime-boost vaccine combination in HIV-negative Thai adults.

@article{Nitayaphan2004SafetyAI,
  title={Safety and immunogenicity of an HIV subtype B and E prime-boost vaccine combination in HIV-negative Thai adults.},
  author={Sorachai Nitayaphan and Punnee Pitisuttithum and Chitraporn Karnasuta and Chirapa Eamsila and Mark S. de Souza and Patricia Morgan and Victoria Polonis and Michael W Benenson and Tom VanCott and Silvia Ratto-Kim and Jerome H. Kim and Darawan Thapinta and Robin P. Garner and Valai Bussaratid and Pricha Singharaj and Raphaelle el-Habib and Sanjay Gurunathan and William L. Heyward and Deborah L. Birx and J. G. Mcneil and Arthur E. Brown},
  journal={The Journal of infectious diseases},
  year={2004},
  volume={190 4},
  pages={
          702-6
        }
}
ALVAC-HIV (vCP1521) and AIDSVAX B/E were evaluated in a phase 1/2 trial of human immunodeficiency virus (HIV)-negative Thai adults. Of 133 volunteers enrolled, 122 completed the trial. There were no serious vaccine-related adverse events, nor were there intercurrent HIV infections. Lymphoproliferative responses to glycoprotein 120 E were induced in 63% of the volunteers, and HIV-specific CD8 cytotoxic T lymphocyte responses were induced in 24%. Antibody responses increased in frequency and… CONTINUE READING

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