Safety and immunogenicity of a tetravalent live-attenuated dengue vaccine in flavivirus naive children.

  title={Safety and immunogenicity of a tetravalent live-attenuated dengue vaccine in flavivirus naive children.},
  author={Sriluck Simasathien and Stephen J Thomas and Veerachai Watanaveeradej and Ananda N Nisalak and C{\'e}lia Barberousse and Bruce L. Innis and Wellington Sun and J. Robert Putnak and Kenneth H. Eckels and Yanee Hutagalung and Robert V Gibbons and Chunlin Zhang and Rafael A. De La Barrera and Richard G Jarman and Wipa Chawachalasai and Mammen P. Mammen},
  journal={The American journal of tropical medicine and hygiene},
  volume={78 3},
A live-attenuated tetravalent dengue virus (DENV) vaccine candidate has been well tolerated and immunogenic in healthy, US flavivirus naive adult volunteers. We conducted a pilot, safety, and immunogenicity trial of the vaccine candidate in healthy Thai children (6-7 years of age) to prepare for its eventual evaluation in Thai infants. In an uncontrolled, open clinical trial, the investigational vaccine was administered on study Days 0 and 180 to seven volunteers residing in Bangkok without… CONTINUE READING
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