Safety and immunogenicity of TA-HPV, a recombinant vaccinia virus expressing modified human papillomavirus (HPV)-16 and HPV-18 E6 and E7 genes, in women with progressive cervical cancer.

@article{Kaufmann2002SafetyAI,
  title={Safety and immunogenicity of TA-HPV, a recombinant vaccinia virus expressing modified human papillomavirus (HPV)-16 and HPV-18 E6 and E7 genes, in women with progressive cervical cancer.},
  author={Andreas M Kaufmann and Peter L. Stern and Elaine M. Rankin and Harald Sommer and Volkmar Nuessler and Achim Schneider and Malcom Adams and Toli S Onon and Thomas Bauknecht and U. F. Wagner and Karlijn Kroon and Julian K Hickling and Christopher M. Boswell and Simon N Stacey and Henry Charles Kitchener and Jennifer Gillard and Jantien Wanders and John St Clair Roberts and Heinz Zwierzina},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2002},
  volume={8 12},
  pages={3676-85}
}
PURPOSE Cervical cancer, the second most common malignancy in women worldwide, is almost invariably associated with infection by human papillomavirus (HPV). HPV-16 or -18 is commonly present in 70% of cervical cancers. HPV-positive tumor cells present antigens of the viral protein in the context of human leukocyte antigen (HLA) class I that can be recognized by CTLs. We have conducted a study in patients with early-stage cervical cancer to assess the safety and immunological effects of… CONTINUE READING

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