• Medicine
  • Published in
    Clinical infectious diseases…
    2005
  • DOI:10.1086/444458

Safety and immunogenicity of 26-valent group a streptococcus vaccine in healthy adult volunteers.

@article{Mcneil2005SafetyAI,
  title={Safety and immunogenicity of 26-valent group a streptococcus vaccine in healthy adult volunteers.},
  author={Shelly A Mcneil and Scott A. Halperin and Joanne Marie Langley and Bruce Smith and Andrew Warren and Geoffrey P. Sharratt and Darlene M Baxendale and Mark A. Reddish and Mary C Hu and Steven D. Stroop and Janine Linden and Louis F. Fries and Peter E. Vink and James B Dale},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={2005},
  volume={41 8},
  pages={
          1114-22
        }
}
BACKGROUND Group A streptococcus (GAS) causes illness ranging from uncomplicated pharyngitis to life-threatening necrotizing fasciitis, toxic shock, and rheumatic fever. Attempts to develop an M protein-based vaccine have been hindered by the fact that some M proteins elicit both protective antibodies and antibodies that cross-react with human tissues. New molecular techniques have allowed the previous obstacles to be largely overcome. METHODS The vaccine is comprised of 4 recombinant… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 44 REFERENCES

Group A streptococcal pharyngitis serotype surveillance in North America, 2000-2002.

  • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2004
VIEW 5 EXCERPTS

The concept of rheumatogenic and nonrheumatogenic group A streptococci

AL Bisno
  • Infect Immun
  • 1980
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Rheumatic fever.

  • A.M.A. archives of internal medicine
  • 1956
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Management of streptococcal pharyngitis reconsidered.

  • Pediatric infectious disease
  • 1985
VIEW 2 EXCERPTS
HIGHLY INFLUENTIAL