Safety and elicitation of humoral and cellular responses in colombian malaria-naive volunteers by a Plasmodium vivax circumsporozoite protein-derived synthetic vaccine.

@article{Herrera2005SafetyAE,
  title={Safety and elicitation of humoral and cellular responses in colombian malaria-naive volunteers by a Plasmodium vivax circumsporozoite protein-derived synthetic vaccine.},
  author={S{\'o}crates Herrera and Anilza Bonelo and Blanca Liliana Perlaza and Olga Fernandez and Leonardo Victoria and Ana Milena Lenis and Liliana Soto and Hugo Hurtado and Lina Mar{\'i}a Acu{\~n}a and Juan Diego V{\'e}lez and Ricardo Palacios and Mario Chen-Mok and Giampietro Corradin and Myriam Ar{\'e}valo-Herrera},
  journal={The American journal of tropical medicine and hygiene},
  year={2005},
  volume={73 5 Suppl},
  pages={3-9}
}
Substantial experimental evidence indicates that the Plasmodium circumsporozoite (CS) protein has great potential as a vaccine candidate. We tested the safety and immunogenicity of vaccines composed of P. vivax CS-derived synthetic peptides. Sixty-nine healthy, malaria-naive volunteers were randomized to receive three injections of placebo or synthetic proteins N, R, or C (10, 30, or 100 microg/dose) in a double-blinded fashion. Vaccines were well tolerated and no serious adverse events were… CONTINUE READING

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