Safety and efficacy of upfront graded administration of trimethoprim-sulfamethoxazole in systemic lupus erythematosus: A retrospective cohort study.

@article{Suyama2016SafetyAE,
  title={Safety and efficacy of upfront graded administration of trimethoprim-sulfamethoxazole in systemic lupus erythematosus: A retrospective cohort study.},
  author={Yasuhiro Suyama and M Okada and Ryo Rokutanda and Chisun Min and Belinda Sass{\'e} and Daiki Kobayashi and Osamu Takahashi and Gautam A. Deshpande and Kazuo Matsui and Yasushi Kawaguchi and Mitsumasa Kishimoto},
  journal={Modern rheumatology},
  year={2016},
  volume={26 4},
  pages={557-61}
}
OBJECTIVES Trimethoprim-sulfamethoxazole (TMP/SMX) is effective as prophylaxis against many infections in immunocompromised patients. However, it is not commonly prescribed for patients with systemic lupus erythematous (SLE) due to the risk of adverse reactions (ADRs). An upfront graded administration protocol for TMP/SMX was adopted, and its safety and… CONTINUE READING