Safety and efficacy of the seven-valent pneumococcal conjugate vaccine: evidence from Northern California

@article{Black2002SafetyAE,
  title={Safety and efficacy of the seven-valent pneumococcal conjugate vaccine: evidence from Northern California},
  author={Steven V Black and Henry R. Shinefield},
  journal={European Journal of Pediatrics},
  year={2002},
  volume={161},
  pages={S127-S131}
}
Pneumococcal disease remains a significant cause of morbidity among young children. A large-scale efficacy trial in the Northern California Kaiser Permanente system (the KP trial) demonstrated that a seven-valent conjugate vaccine (PCV) is safe and immunogenic in young children and effective in preventing both invasive pneumococcal disease caused by vaccine serotypes (97.4% efficacy) and episodes of otitis media (7.0% efficacy). Since the publication of the results of the KP trial in 2000, we… CONTINUE READING
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