Safety and efficacy of sofosbuvir-containing regimens in hepatitis C-infected patients with impaired renal function.

@article{Saxena2016SafetyAE,
  title={Safety and efficacy of sofosbuvir-containing regimens in hepatitis C-infected patients with impaired renal function.},
  author={Varun Saxena and Farrukh M. Koraishy and Meghan E. Sise and J K Lim and M{\^o}nica Luisa Rappi Schmidt and Raymond Tsang Chi Chung and Annmarie H Liapakis and David R. Nelson and Michael W. Fried and Norah A. Terrault},
  journal={Liver international : official journal of the International Association for the Study of the Liver},
  year={2016},
  volume={36 6},
  pages={807-16}
}
BACKGROUND & AIMS Renal clearance is the major elimination pathway for sofosbuvir (SOF). We assessed the safety and efficacy of SOF-containing regimens in patients with varying baseline estimated glomerular filtration rate (eGFR). METHODS HCV-TARGET database is a multicentre, longitudinal 'real-world' treatment cohort. RESULTS A total of 1789 patients… CONTINUE READING