Safety and efficacy of high-dose rhesus-human reassortant rotavirus vaccines--report of the National Multicenter Trial. United States Rotavirus Vaccine Efficacy Group.

@article{Rennels1996SafetyAE,
  title={Safety and efficacy of high-dose rhesus-human reassortant rotavirus vaccines--report of the National Multicenter Trial. United States Rotavirus Vaccine Efficacy Group.},
  author={Margaret B. Rennels and Roger I. Glass and Penelope H. Dennehy and David I. Bernstein and Michael E. Pichichero and Elio Zito and Michael E. Mack and Bruce L Davidson and Albert Z. Kapikian},
  journal={Pediatrics},
  year={1996},
  volume={97 1},
  pages={
          7-13
        }
}
OBJECTIVE Rotavirus is a leading cause of morbidity and mortality from dehydrating gastroenteritis in infants and young children worldwide. Virtually every child is infected by age 4 years, justifying universal childhood immunization when a safe and effective vaccine is available. We report the results of a multicenter, placebo-controlled field trial in the United States of monovalent serotype 1 and tetravalent (TV) rhesus-human reassortant rotavirus vaccines (RRVs). DESIGN In this randomized… CONTINUE READING
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