Safety and efficacy of everolimus in Chinese patients with metastatic renal cell carcinoma resistant to vascular endothelial growth factor receptor-tyrosine kinase inhibitor therapy: an open-label phase 1b study

@inproceedings{Guo2012SafetyAE,
  title={Safety and efficacy of everolimus in Chinese patients with metastatic renal cell carcinoma resistant to vascular endothelial growth factor receptor-tyrosine kinase inhibitor therapy: an open-label phase 1b study},
  author={Jishun Guo and Yiran Huang and Xu Zhang and Fang Zhou and Yinghao Sun and Shukui Qin and Zhangqun Ye and Hui Wang and Annette Jappe and Patrick Straub and Nicoletta Pirotta and Sven Gogov},
  booktitle={BMC Cancer},
  year={2012}
}
In China, there are currently no approved therapies for the treatment of metastatic renal cell carcinoma (mRCC) following progression with vascular endothelial growth factor (VEGF)-targeted agents. In the phase 3 RECORD-1 trial, the mammalian target of rapamycin (mTOR) inhibitor everolimus afforded clinical benefit with good tolerability in Western patients with mRCC whose disease had progressed despite VEGF receptor-tyrosine kinase inhibitor (VEGFr-TKI) therapy. This phase 1b study was… CONTINUE READING
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