Safety and efficacy of convection-enhanced delivery of gemcitabine or carboplatin in a malignant glioma model in rats.

@article{Degen2003SafetyAE,
  title={Safety and efficacy of convection-enhanced delivery of gemcitabine or carboplatin in a malignant glioma model in rats.},
  author={J. W. Degen and Stuart Walbridge and Alexander O. Vortmeyer and Edward H. Oldfield and Russell R. Lonser},
  journal={Journal of neurosurgery},
  year={2003},
  volume={99 5},
  pages={893-8}
}
OBJECT Convection-enhanced delivery (CED) can be used safely to perfuse regions of the central nervous system (CNS) with therapeutic agents in a manner that bypasses the blood-brain barrier (BBB). These features make CED a potentially ideal method for the distribution of potent chemotherapeutic agents with certain pharmacokinetic properties to tumors of the… CONTINUE READING