Safety and efficacy of coformulated efavirenz/emtricitabine/tenofovir single-tablet regimen in treatment-naive patients infected with HIV-1.

@article{Gallien2015SafetyAE,
  title={Safety and efficacy of coformulated efavirenz/emtricitabine/tenofovir single-tablet regimen in treatment-naive patients infected with HIV-1.},
  author={S{\'e}bastien Gallien and Philippe Flandre and Nga T. T. Nguyen and Nathalia Coelho de Castro and Jean-Michel Molina and Constance Delaugerre},
  journal={Journal of medical virology},
  year={2015},
  volume={87 2},
  pages={187-91}
}
Due to the differences between bioavailability of efavirenz (EFV) and tenofovir (TDF), the single-tablet regimen of EFV/emtricitabine (FTC)/TDF is not approved as initial antiretroviral therapy (ART) in Europe by the European Medical Agency. To compare clinical, immunological, and virological outcomes between co-formulated TDF/FTC+EFV and the co-formulated EFV/FTC/TDF single-tablet regimen in patients infected with HIV-1 naive to ART, the data of patients (n = 231) who initiated either TDF/FTC… CONTINUE READING
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