Safety and efficacy of buccal midazolam versus rectal diazepam for emergency treatment of seizures in children: a randomised controlled trial

@article{McIntyre2005SafetyAE,
  title={Safety and efficacy of buccal midazolam versus rectal diazepam for emergency treatment of seizures in children: a randomised controlled trial},
  author={John D. McIntyre and Stephen E. Robertson and Elizabeth Norris and Richard T Appleton and William P Whitehouse and B. H. Phillips and Tim Martland and Kathleen M Berry and Jacqueline Collier and Stephanie L. Maatta Smith and Imti Choonara},
  journal={The Lancet},
  year={2005},
  volume={366},
  pages={205-210}
}
BACKGROUND Rectal diazepam and buccal midazolam are used for emergency treatment of acute febrile and afebrile (epileptic) seizures in children. We aimed to compare the safety and efficacy of these drugs. METHODS A multicentre, randomised controlled trial was undertaken to compare buccal midazolam with rectal diazepam for emergency-room treatment of children aged 6 months and older presenting to hospital with active seizures and without intravenous access. The dose varied according to age… CONTINUE READING
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