Safety and efficacy of botulinum toxin type A following long-term use.

@article{Naumann2006SafetyAE,
  title={Safety and efficacy of botulinum toxin type A following long-term use.},
  author={Markus K Naumann and Alberto Albanese and Florian R. Heinen and Guy Molenaers and Maja Relja},
  journal={European journal of neurology},
  year={2006},
  volume={13 Suppl 4},
  pages={35-40}
}
Botulinum toxin serotype A (BoNT-A) has long heritage of use leading to confidence in its safety and efficacy. The application of BoNT-A does not lead to persistent histological changes in the nerve terminal or the target muscle. Clinical trials defined the safety and tolerability profile of BoNT-A across common therapeutic indications and showed an incidence of adverse events of approximately 25% in the BoNT-A-treated group compared with 15% in the control group. Focal weakness was the only… CONTINUE READING

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