Safety and efficacy of angiotensin-converting enzyme inhibitors in symptomatic severe aortic stenosis: Symptomatic Cardiac Obstruction-Pilot Study of Enalapril in Aortic Stenosis (SCOPE-AS).

@article{Chockalingam2004SafetyAE,
  title={Safety and efficacy of angiotensin-converting enzyme inhibitors in symptomatic severe aortic stenosis: Symptomatic Cardiac Obstruction-Pilot Study of Enalapril in Aortic Stenosis (SCOPE-AS).},
  author={Anand Chockalingam and Sudhir Venkatesan and Tulsi Subramaniam and Vasudevan Jagannathan and Satheesh Elangovan and Ramasamy Alagesan and Ganesan Gnanavelu and Smrita Dorairajan and B. Phani Krishna and Vijayaratna Chockalingam},
  journal={American heart journal},
  year={2004},
  volume={147 4},
  pages={E19}
}
BACKGROUND Animal models have demonstrated a benefit of angiotensin-converting enzyme inhibitors (ACEI) in experimental aortic stenosis (AS), and intravenous nitroprusside has shown hemodynamic improvements in AS with left ventricular (LV) dysfunction. Although routinely used in most heart failure situations, ACEI are avoided in AS because of the risk of hypotension. We aimed to determine the clinical tolerance and efficacy of the ACEI enalapril in the setting of symptomatic severe AS… CONTINUE READING
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