Safety and efficacy of a multicenter study using intraarterial chemotherapy in conjunction with osmotic opening of the blood-brain barrier for the treatment of patients with malignant brain tumors.

@article{Doolittle2000SafetyAE,
  title={Safety and efficacy of a multicenter study using intraarterial chemotherapy in conjunction with osmotic opening of the blood-brain barrier for the treatment of patients with malignant brain tumors.},
  author={Nancy D. Doolittle and Meg Miner and Walter A. Hall and Tali Siegal and Estaquier Jerome and Eva Osztie and Leslie D. McAllister and Joseph S. Bubalo and Dale Kraemer and David Fortin and RH. Nixon and Leslie L. Muldoon and Edward A Neuwelt},
  journal={Cancer},
  year={2000},
  volume={88 3},
  pages={
          637-47
        }
}
BACKGROUND The aim of this study was to determine the safety and efficacy of intraarterial chemotherapy with osmotic opening of the blood-brain barrier (BBB) for the treatment of malignant brain tumors when administered across multiple centers. METHODS Patients with primary central nervous system lymphoma (PCNSL), primitive neuroectodermal tumor (PNET), germ cell tumor, cancer metastasis to the brain, or low or high grade glioma were eligible. Prior to entry, magnetic resonance imaging or… CONTINUE READING
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