Safety and efficacy of N-acetylcysteine in children with non-acetaminophen-induced acute liver failure.

@article{Kortsalioudaki2008SafetyAE,
  title={Safety and efficacy of N-acetylcysteine in children with non-acetaminophen-induced acute liver failure.},
  author={Christine Kortsalioudaki and Rachel R. Taylor and Paul Cheeseman and Sanjay Bansal and Giorgina Mieli-Vergani and Anil Dhawan},
  journal={Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society},
  year={2008},
  volume={14 1},
  pages={25-30}
}
Acute liver failure (ALF) carries a high mortality in children. N-acetylcysteine (NAC), an antioxidant agent that replenishes mitochondrial and cytosolic glutathione stores, has been used in the treatment of late acetaminophen-induced ALF and non-acetaminophen-induced ALF. In our unit, NAC was introduced as additional treatment for non-acetaminophen-induced ALF in 1995. The aim of this study was to evaluate the safety and efficacy of NAC in children with ALF not caused by acetaminophen… CONTINUE READING

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