Safety and effectiveness of recombinant human bone morphogenetic protein-2 for spinal fusion: a meta-analysis of individual-participant data.

@article{Simmonds2013SafetyAE,
  title={Safety and effectiveness of recombinant human bone morphogenetic protein-2 for spinal fusion: a meta-analysis of individual-participant data.},
  author={Mark Simmonds and Jennifer V. E. Brown and Morag K Heirs and Julian P. T. Higgins and Richard John Mannion and Mark Rodgers and Lesley Anne Stewart},
  journal={Annals of internal medicine},
  year={2013},
  volume={158 12},
  pages={877-89}
}
BACKGROUND Recombinant human bone morphogenetic protein-2 (rhBMP-2) is widely used to promote fusion in spinal surgery, but its safety has been questioned. PURPOSE To evaluate the effectiveness and safety of rhBMP-2. DATA SOURCES Individual-participant data obtained from the sponsor or investigators and data extracted from study publications identified by systematic bibliographic searches through June 2012. STUDY SELECTION Randomized, controlled trials of rhBMP-2 versus iliac crest bone… CONTINUE READING
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