Safety and effectiveness of drug-eluting stents versus bare-metal stents in elderly patients with small coronary vessel disease.

Abstract

BACKGROUND Drug-eluting stents (DES) are more effective than bare-metal stents (BMS) in small coronary vessel disease. Whether this is true in elderly patients, it is unclear, as frailty and a high rate of comorbidities could increase the rate of DES-related complications. AIMS To assess procedural and long-term clinical outcomes of elderly patients with small vessel disease treated with DES or BMS. METHODS Consecutive elderly patients (≥ 75 years old) treated with stenting of native small coronary arteries (reference vessel diameter and implanted stent<3mm) were recruited during 2004-2008. Procedural and long-term clinical outcomes were compared between patients treated with BMS and DES. Propensity score-adjusted logistic regression analysis was performed to account for potential selection bias. RESULTS Among 293 patients (175 BMS, 118 DES), peri-procedural myocardial infarction (12 [7%] vs. 5 [4%]; P=0.35) and blood transfusions (3 [2%] vs. 0; P=0.08) were not significantly different between the BMS and DES groups. Clinical follow-up (96% of patients, median [interquartile range] follow-up 3.5 [2.4] years) showed significantly lower adjusted major adverse cardiac events (hazard ratio [HR] 0.42, 95% confidence interval [CI] 0.24-0.72; P=0.002) and target vessel revascularization (TVR) (HR 0.33, 95% CI 0.14-0.76; P=0.009) in the DES group. No significant differences were observed between the groups in terms of death, myocardial infarction, stent thrombosis or bleeding. CONCLUSIONS In this retrospective, non-randomized analysis of the treatment of small vessel disease in elderly patients, DES were as safe and more effective than BMS with a significant reduction in TVR.

DOI: 10.1016/j.acvd.2013.06.056
010020030020162017
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@article{Puymirat2013SafetyAE, title={Safety and effectiveness of drug-eluting stents versus bare-metal stents in elderly patients with small coronary vessel disease.}, author={{\'E}tienne Puymirat and Fabio Mangiacapra and Aaron J. Peace and Y. Ntarladimas and Micaela Conte and Jozef J. Bartunek and Marc Vanderheyden and William Wijns and Bernard de Bruyne and Emanuele Barbato}, journal={Archives of cardiovascular diseases}, year={2013}, volume={106 11}, pages={554-61} }