Safety and effect on rod function of ACU-4429, a novel small-molecule visual cycle modulator.

@article{Kubota2012SafetyAE,
  title={Safety and effect on rod function of ACU-4429, a novel small-molecule visual cycle modulator.},
  author={Ryo Kubota and Nancy L Boman and Robert David and Suresh Mallikaarjun and Shiva Kumar Patil and David R Birch},
  journal={Retina},
  year={2012},
  volume={32 1},
  pages={183-8}
}
BACKGROUND ACU-4429 is a first in class small-molecule visual cycle modulator that inhibits the isomerase complex and, in mouse models of retinal degeneration, prevents the accumulation of A2E. The purpose of this study was to assess the tolerability, pharmacokinetics, pharmacodynamics, and safety of a single, orally administered dose of ACU-4429 in healthy subjects. METHODS Sequential cohorts were administered single doses ranging from 2 mg to 75 mg. Full-field electroretinograms were… CONTINUE READING
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