Safety and clinical activity of pembrolizumab for treatment of recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-012): an open-label, multicentre, phase 1b trial.

@article{Seiwert2016SafetyAC,
  title={Safety and clinical activity of pembrolizumab for treatment of recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-012): an open-label, multicentre, phase 1b trial.},
  author={Tanguy Y. Seiwert and Barbara A Burtness and Ranee Mehra and Jared M Weiss and Raanan Berger and Joseph Paul Eder and Karl H. Heath and Terrill K. Mcclanahan and Jared K Lunceford and Christine K. Gause and Jonathan D. Cheng and Laura Quan Man Chow},
  journal={The Lancet. Oncology},
  year={2016},
  volume={17 7},
  pages={
          956-965
        }
}
BACKGROUND Patients with recurrent or metastatic squamous cell carcinoma of the head and neck have few treatment options. We aimed to assess the safety, tolerability, and antitumour activity of pembrolizumab, a humanised anti-programmed death receptor 1 (PD-1) antibody, in patients with PD-L1-positive recurrent or metastatic squamous cell carcinoma of the head and neck. METHODS This study was an open-label, multicentre, phase 1b trial of patients with recurrent or metastatic squamous cell… CONTINUE READING
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