Safety and activity of crizotinib for paediatric patients with refractory solid tumours or anaplastic large-cell lymphoma: a Children's Oncology Group phase 1 consortium study.

@article{Mosse2013SafetyAA,
  title={Safety and activity of crizotinib for paediatric patients with refractory solid tumours or anaplastic large-cell lymphoma: a Children's Oncology Group phase 1 consortium study.},
  author={Yael Mosse and M. S. Lim and Stephan D. Voss and Keith D. Wilner and Katherine L Ruffner and Julie Lalibert{\'e} and Delphine C. M. Rolland and Frank M Balis and John M. Maris and Brenda J. Weigel and Ashish Mark Ingle and Charlotte Hsieh Ahern and Peter C. Adamson and Susan M. Blaney},
  journal={The Lancet. Oncology},
  year={2013},
  volume={14 6},
  pages={472-80}
}
BACKGROUND Various human cancers have ALK gene translocations, amplifications, or oncogenic mutations, such as anaplastic large-cell lymphoma, inflammatory myofibroblastic tumours, non-small-cell lung cancer (NSCLC), and neuroblastoma. Therefore, ALK inhibition could be a useful therapeutic strategy in children. We aimed to determine the safety, recommended phase 2 dose, and antitumour activity of crizotinib in children with refractory solid tumours and anaplastic large-cell lymphoma. METHODS… CONTINUE READING
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: large - scale immunohistochemical screening by the intercalated antibody - enhanced polymer method

  • Y Chen, J Takita, YL Choi
  • 2012

anaplastic lymphoma kinase fusions in renal cancer: large-scale immunohistochemical screening by the intercalated antibody-enhanced polymer method

  • J Takita, YL Choi
  • Cancer
  • 2012

Diff erential inhibitor sensitivity of anaplastic lymphoma kinase variants found in neuroblastoma

  • JG Christensen, HY Zou, ME Arango
  • Sci Transl Med
  • 2011

Identifi cation of oncogenic point mutations and hyperphosphorylation of anaplastic lymphoma kinase in lung cancer

  • AK Murugan, M Xing
  • Neoplasia
  • 2011

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