Safety and Toxicological Evaluation of a Novel, Standardized 3-O-Acetyl-11-keto-β-Boswellic Acid (AKBA)-Enriched Boswellia serrata Extract (5-Loxin®)

@article{Lalithakumari2006SafetyAT,
  title={Safety and Toxicological Evaluation of a Novel, Standardized 3-O-Acetyl-11-keto-$\beta$-Boswellic Acid (AKBA)-Enriched Boswellia serrata Extract (5-Loxin{\textregistered})},
  author={K Lalithakumari and Alluri V. Krishnaraju and Krishanu Sengupta and Gottumukkala Venkata Subbaraju and Ajay Kumar Chatterjee},
  journal={Toxicology Mechanisms and Methods},
  year={2006},
  volume={16},
  pages={199 - 226}
}
The novel anti-inflammatory properties of the gum resin derived from Boswellia serrata, also known as Salai guggal in Ayurvedic medicine, are well recognized and highly recommended for human consumption. The active constituents of the gum resin are boswellic acids (BAs). Among the BAs, AKBA potently inhibits 5-lipoxygenase product formation with an IC50 of 1.5 m μM. We developed a novel Boswellia serrata extract (5-Loxin®) enriched with 30% AKBA (US Patent 2004/0073060A1). The genetic basis of… 
Cellular and molecular mechanisms of anti-inflammatory effect of Aflapin: a novel Boswellia serrata extract
TLDR
In comparison with BE-30, Aflapin provides more potential benefits in recovering articular cartilage damage or protection from proteolytic degradation due to inflammatory insult in arthritis such as osteoarthritis or rheumatoid arthritis.
Measurement of 3-acetyl-11-keto-beta-boswellic acid and 11-keto-beta-boswellic acid in Boswellia serrata Supplements Administered to Dogs
TLDR
A large variation of boswellic acid concentrations in market formulations claiming to contain BSE is demonstrated, with products claimed to contain AKBA containing higher concentrations of AKBA than other products and the need for independent laboratories to quantify concentrations of active ingredients in supplements containing BSE confirmed.
Safety and toxicological evaluation of Aflapin®: A novel Boswellia-derived anti-inflammatory product
TLDR
A battery of acute and sub-acute toxicity studies were conducted in various animal models according to the OECD test guidelines to demonstrate broad spectrum safety of Aflapin in animal models.
In vivo genotoxicity evaluation of a plant based antiarthritic and anticancer therapeutic agent Boswelic acids in rodents.
Identification of Potential Antiseizure Agents in Boswellia sacra using In Vivo Zebrafish and Mouse Epilepsy Models.
TLDR
This study and the preclinical evaluation performed indicate that β-boswellic acid, common to various species of Boswellia, has some potential as an antiseizure agent.
...
1
2
3
4
...

References

SHOWING 1-10 OF 16 REFERENCES
Mechanism of antiinflammatory actions of curcumine and boswellic acids.
Boswellic acids: novel, specific, nonredox inhibitors of 5-lipoxygenase.
TLDR
The data strongly suggest that BAs are specific, nonreducing-type inhibitors of the 5-LO product formation either interacting directly with the5-LO or blocking its translocation.
Inhibition of leukotriene B4 formation in rat peritoneal neutrophils by an ethanolic extract of the gum resin exudate of Boswellia serrata.
TLDR
It is concluded that the activity of the 5- LOx itself represents the side of inhibition by the gum resin extract, and an inhibition of 5-LOx catalysed mediator synthesis might be involved in the previously reported anti-inflammatory activity in vivo.
Human genome screen to identify the genetic basis of the anti-inflammatory effects of Boswellia in microvascular endothelial cells.
TLDR
In an in vivo model of carrageenan-induced rat paw inflammation, a significant antiinflammatory property of BE is observed consistent with the in vitro findings and warrant further research aimed at identifying the signaling mechanisms by which BE exerts its anti-inflammatory effects.
Stimulation of leukotriene synthesis in intact polymorphonuclear cells by the 5-lipoxygenase inhibitor 3-oxo-tirucallic acid.
TLDR
Natural tetracyclic triterpenes are defined, which act as inhibitors of the 5- LO in the cell-free assay, initiate 5-LO activation by a MEK-inhibitor sensitive mechanism and potentiate stimulated product synthesis in intact cells.
Boswelliasäuren (Inhaltsstoffe des Weihrauchs)als wirksame Prinzipien zur Behandlung chronisch entzündlicher Erkrankungen
TLDR
In clinical trials promising results were observed in patients with rheumatoid arthritis, chroniccolitis, ulcerative colitis, Crohn's disease, bronchial asthma und peritumoral brains edemas.
Effects of gum resin of Boswellia serrata in patients with chronic colitis.
TLDR
This study shows that a gum resin preparation from Boswellia serrata could be effective in the treatment of chronic colitis with minimal side effects.
Effects of Boswellia serrata gum resin in patients with bronchial asthma: results of a double-blind, placebo-controlled, 6-week clinical study.
TLDR
The data show a definite role of gum resin of Boswellia serrata in the treatment of bronchial asthma and improvement of disease as evident by disappearance of physical symptoms and signs.
Stress, diet and alcohol‐induced oxidative gastrointestinal mucosal injury in rats and protection by bismuth subsalicylate
TLDR
The results demonstrate that physical and chemical stressors can induce gastrointestinal oxidative stress and mucosal injury through enhanced production of reactive oxygen species, and that bismuth subsalicylate can significantly attenuate gastrointestinal injury by scavenging these reactive oxygen Species.
Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee--a randomized double blind placebo controlled trial.
TLDR
BSE was well tolerated by the subjects except for minor gastrointestinal ADRs and the frequency of swelling in the knee joint was decreased, and the observed differences between drug treated and placebo being statistically significant, are clinically relevant.
...
1
2
...