Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

  title={Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine},
  author={Fernando P. Polack and Stephen J. Thomas and Nicholas R E Kitchin and Judith Absalon and Alejandra C Gurtman and Stephen Lockhart and John L. Perez and Gonzalo P{\'e}rez Marc and Edson Duarte Moreira and Cristiano A F Zerbini and Ruth Bailey and Kena A. Swanson and Satrajit Roychoudhury and Kenneth J. Koury and Ping Li and Warren Vincent Kalina and David Cooper and Robert W. Frenck and Laura L. Hammitt and {\"O}zlem T{\"u}reci and Haylene Nell and Axel Schaefer and Serhat {\"U}nal and Dina B Tresnan and Susan H. Mather and Philip R. Dormitzer and Uğur Şahin and Kathrin U. Jansen and William C Gruber},
  journal={The New England Journal of Medicine},
Abstract Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the resulting coronavirus disease 2019 (Covid-19) have afflicted tens of millions of people in a worldwide pandemic. Safe and effective vaccines are needed urgently. Methods In an ongoing multinational, placebo-controlled, observer-blinded, pivotal efficacy trial, we randomly assigned persons 16 years of age or older in a 1:1 ratio to receive two doses, 21 days apart, of either placebo or the BNT162b2… 

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