Safety and Efficacy of Saffron (Crocus sativus L.) for Treating Mild to Moderate Depression: A Systematic Review and Meta-analysis.

  title={Safety and Efficacy of Saffron (Crocus sativus L.) for Treating Mild to Moderate Depression: A Systematic Review and Meta-analysis.},
  author={Li-li Dai and Lingyan Chen and Wenjing Wang},
  journal={Journal of Nervous \& Mental Disease},
BACKGROUND Herbal remedies are becoming increasingly popular for the treatment of depression. Recently, accumulating evidences reveal a positive effect of saffron (Crocus sativus L.) in relieving depressive symptoms. The objective of this meta-analysis was to assess the safety and efficacy of saffron in treating mild to moderate depression by synthesizing all available data. MATERIALS AND METHODS Relevant studies were retrieved from electronic databases and cross-checking of reference lists… 
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