Safety and Efficacy of Saffron (Crocus sativus L.) for Treating Mild to Moderate Depression: A Systematic Review and Meta-analysis.

@article{Dai2020SafetyAE,
  title={Safety and Efficacy of Saffron (Crocus sativus L.) for Treating Mild to Moderate Depression: A Systematic Review and Meta-analysis.},
  author={Li-li Dai and Lingyan Chen and Wenjing Wang},
  journal={Journal of Nervous \& Mental Disease},
  year={2020}
}
BACKGROUND Herbal remedies are becoming increasingly popular for the treatment of depression. Recently, accumulating evidences reveal a positive effect of saffron (Crocus sativus L.) in relieving depressive symptoms. The objective of this meta-analysis was to assess the safety and efficacy of saffron in treating mild to moderate depression by synthesizing all available data. MATERIALS AND METHODS Relevant studies were retrieved from electronic databases and cross-checking of reference lists… 
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TLDR
Saffron was effective in the treatment of MDD and had comparable efficacy to synthetic antidepressants, and was also a safe drug without serious adverse events reported.
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TLDR
Clinical trials conducted on women with premenstrual syndrome showed that saffron could reduce suffering symptoms more than the placebo and similar to standard treatments, and additional clinical trials on effects of saffrons on erection dysfunction, allergies, cardiovascular and immune system as well as its safety, toxicity and human pharmacokinetics are reviewed herein.
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TLDR
Saffron supplements had a significant effect on the BDI and BAI scores of subjects in comparison to placebo at the 12 week time-point (p<0.001).
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TLDR
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TLDR
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